Get out your record books: the largest python ever harvested from the Florida Everglades is 17 foot, 7 inches long and 165 pounds. After tagging it and tracking it to its breeding grounds, scientists killed the monster and froze it for study, finding a whopping 87 eggs in the beast.
The problem is not that there are no natural predators of the beast in the Everglades. I'm just about dead certain the problem is its actual natural predator is legally prevented from organizing and profiting from hunting it. Put a bounty up for each snake caught, and defray the cost with a permit system and taxing the product. We once nearly emptied the Everglades of alligators, ferchrissake. The snakes wouldn't have a chance.