Well, the skinny-nerdy-whiteboy approach has worked for this franchise before:
"That '70s Show" star Topher Grace has joined the lineup of "Spider-Man 3," in which he will play one of two villains.
The film's distributor, Columbia Pictures, declined to give further details about his role.
As long as the writing's good, the makup artists can pretty much do anything with anyone. Hey, if Michael Keaton can pull off Batman...